Yoann SEELEUTHNER | Institut Imagine

Presentation

Yoann SEELEUTHNER

Human genetics of infectious diseases

Contact :

yoann.seeleuthner@institutimagine.org

About

Scientific Publications

Publications

2026

Humans homozygous for rare or common hypomorphic IL23R variants are prone to ..., J Exp Med
2026

GDIv2: improving variant selection from human exomes., Bioinform Adv
2026

Human LFA-1 governs T cell immune surveillance of the skin., Sci Immunol
2026

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs..., Nat Immunol
2025

A promoter variant underlying Wiskott-Aldrich syndrome in two kindreds., J Hum Immun
2025

A human YEATS4 variant confers resistance to TST and IGRA conversion despite ..., Genome Med
2025

Intronic branchpoint-to-acceptor variants underlying inborn errors of immunity., J Hum Immun
2025

Human LY9 governs CD4 T cell IFN-γ immunity to ., Sci Immunol
2024

Autoinflammation in patients with leukocytic CBL loss of heterozygosity is ca..., J Clin Invest
2024

Tuberculosis in otherwise healthy adults with inherited TNF deficiency., Nature
2024

FLT3L governs the development of partially overlapping hematopoietic lineages..., Cell
2024

Helper T cell immunity in humans with inherited CD4 deficiency., J Exp Med
2024

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 o..., J Clin Invest
2024

The immunopathological landscape of human pre-TCRα deficiency: From rare to c..., Science
2023

Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to ..., Cell
2023

Rare predicted loss-of-function variants of type I IFN immunity genes are ass..., Genome Med
2023

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria., Cell
2022

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculo..., J Exp Med
2021

Controlling for human population stratification in rare variant association s..., Sci Rep
2021

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life..., Sci Immunol
2021

Taking population stratification into account by local permutations in rare-v..., Genet Epidemiol
2021

Detection of homozygous and hemizygous complete or partial exon deletions by ..., NAR Genom Bioinform
2021

Genome-wide association study of resistance to Mycobacterium tuberculosis inf..., PLoS Genet
2021

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever..., J Exp Med
2020

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19., Science
2020

Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science
2020

Common homozygosity for predicted loss-of-function variants reveals both redu..., Proc Natl Acad Sci U S A
2020

Inherited human IFN-γ deficiency underlies mycobacterial disease., J Clin Invest
2019

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reacti..., J Exp Med
2019

Homozygosity for P1104A underlies tuberculosis in about 1% of patients in a ..., Proc Natl Acad Sci U S A
2018

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23., Sci Immunol

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Presentation

About

Scientific Publications

Humans homozygous for rare or common hypomorphic IL23R variants are prone to ..., J Exp Med

GDIv2: improving variant selection from human exomes., Bioinform Adv

Human LFA-1 governs T cell immune surveillance of the skin., Sci Immunol

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs..., Nat Immunol

A promoter variant underlying Wiskott-Aldrich syndrome in two kindreds., J Hum Immun

A human YEATS4 variant confers resistance to TST and IGRA conversion despite ..., Genome Med

Intronic branchpoint-to-acceptor variants underlying inborn errors of immunity., J Hum Immun

Human LY9 governs CD4 T cell IFN-γ immunity to ., Sci Immunol

Autoinflammation in patients with leukocytic CBL loss of heterozygosity is ca..., J Clin Invest

Tuberculosis in otherwise healthy adults with inherited TNF deficiency., Nature

FLT3L governs the development of partially overlapping hematopoietic lineages..., Cell

Helper T cell immunity in humans with inherited CD4 deficiency., J Exp Med

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB115:02 o..., J Clin Invest*

The immunopathological landscape of human pre-TCRα deficiency: From rare to c..., Science

Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to ..., Cell

Rare predicted loss-of-function variants of type I IFN immunity genes are ass..., Genome Med

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria., Cell

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculo..., J Exp Med

Controlling for human population stratification in rare variant association s..., Sci Rep

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life..., Sci Immunol

Taking population stratification into account by local permutations in rare-v..., Genet Epidemiol

Detection of homozygous and hemizygous complete or partial exon deletions by ..., NAR Genom Bioinform

Genome-wide association study of resistance to Mycobacterium tuberculosis inf..., PLoS Genet

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever..., J Exp Med

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19., Science

Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science

Common homozygosity for predicted loss-of-function variants reveals both redu..., Proc Natl Acad Sci U S A

Inherited human IFN-γ deficiency underlies mycobacterial disease., J Clin Invest

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reacti..., J Exp Med

Homozygosity for P1104A underlies tuberculosis in about 1% of patients in a ..., Proc Natl Acad Sci U S A

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23., Sci Immunol

Presentation

About

Scientific Publications

Humans homozygous for rare or common hypomorphic IL23R variants are prone to ..., J Exp Med

GDIv2: improving variant selection from human exomes., Bioinform Adv

Human LFA-1 governs T cell immune surveillance of the skin., Sci Immunol

Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs..., Nat Immunol

A promoter variant underlying Wiskott-Aldrich syndrome in two kindreds., J Hum Immun

A human YEATS4 variant confers resistance to TST and IGRA conversion despite ..., Genome Med

Intronic branchpoint-to-acceptor variants underlying inborn errors of immunity., J Hum Immun

Human LY9 governs CD4 T cell IFN-γ immunity to ., Sci Immunol

Autoinflammation in patients with leukocytic CBL loss of heterozygosity is ca..., J Clin Invest

Tuberculosis in otherwise healthy adults with inherited TNF deficiency., Nature

FLT3L governs the development of partially overlapping hematopoietic lineages..., Cell

Helper T cell immunity in humans with inherited CD4 deficiency., J Exp Med

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB1*15:02 o..., J Clin Invest

The immunopathological landscape of human pre-TCRα deficiency: From rare to c..., Science

Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to ..., Cell

Rare predicted loss-of-function variants of type I IFN immunity genes are ass..., Genome Med

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria., Cell

Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculo..., J Exp Med

Controlling for human population stratification in rare variant association s..., Sci Rep

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life..., Sci Immunol

Taking population stratification into account by local permutations in rare-v..., Genet Epidemiol

Detection of homozygous and hemizygous complete or partial exon deletions by ..., NAR Genom Bioinform

Genome-wide association study of resistance to Mycobacterium tuberculosis inf..., PLoS Genet

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever..., J Exp Med

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19., Science

Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science

Common homozygosity for predicted loss-of-function variants reveals both redu..., Proc Natl Acad Sci U S A

Inherited human IFN-γ deficiency underlies mycobacterial disease., J Clin Invest

Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reacti..., J Exp Med

Homozygosity for P1104A underlies tuberculosis in about 1% of patients in a ..., Proc Natl Acad Sci U S A

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23., Sci Immunol

Neutralizing IFN-γ autoantibodies are rare and pathogenic in HLA-DRB115:02 o..., J Clin Invest*